Back in the first episode of The Last of Us, one of the things that we found out was the fact that Ellie was so important to Marlene and the Fireflies due to the fact that she was infected by the CBI but was somehow immune to the effects of the infection. Of course, this was a fact that surprised both Joel and Tess because they didn’t know

The HBO series explored the virus' nature again in its season finale by explaining why Ellie is immune to the infection. The young girl discovered she was immune after being bitten by a lone infected in an abandoned mall, and after weeks of no symptoms, she became a rarity in the world. Even if The Last of Us occasionally lacks enough danger
The future is bleak. The 1968 storyline in The Last of Us features John Hannah as Dr. Neuman.He is on a talk show that is more of a debate on whether or not something like a Cordyceps could mutate
While The Last of Us games never explicitly reference why Ellie is immune, this storyline is seemingly actually be canon due to a deep-cut reference. When playing as Ellie after Joel is
Ellie's immune because that particular strain of cordyceps mutated inside her, whereas no other strain did. That mutation created a protection against the harmful effects of the virus. Truth is, there is nothing special about Ellie's DNA. It could have been anybody who got infected with that one-in-a-billion strain. The answer to why Ellie is immune has yet to be fully explained in the show. Ellie was born in 2019 when the Cordyceps infection had already spread around the world. The Last of Us series begins The Last of Us’ “Left Behind” is the show’s latest in an already long line of detailing the night Ellie discovered she was immune to the Cordyceps fungus, and also lost her best friend The season 1 finale of The Last of Us on HBO Max opens with a harrowing scene: a pregnant woman in labor runs through the forest and hides in an abandoned house, propping a chair against the door
Ellie was lucky she survived past the point where she should have turned and Marlene protected her and kept it secret to get her out of town. In this game, Ellie is the only immune person. They’re probably more if you read fanfiction, but if we’re just going off of the game alone, Ellie is the only one.
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